Cyclic Vomiting Syndrome Association



Cyclic Vomiting Syndrome

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A short overview article about CVS in English, and in all the Nordic languages. 

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Information on CVS

Here you can find extensive information on CVS. These articles are written in English

Library of

Articles and Studies

A list of studies and review articles about CVS.


Information on CVS

1. What is CVS?

Cyclic vomiting syndrome, or cyclical vomiting syndrome, (CVS) is a chronic functional condition of unknown cause characterized by recurring attacks of intense nausea, vomiting, and sometimes abdominal pain, headaches,

2. Pathophysiology and Etiology

Even though the etiology and pathophysiology of CVS are not known, studies have suggested several potential brain-gut mechanisms.

3. Cyclic Vomiting Syndrome and Mitochondrial Dysfunction and treatment

Mitochondria are small organelles within the cell responsible for energy production and other critical functions.

4. CVS subgroups

Subcategories of CVS have been identified, including CVS plus, catamenial CVS, and Sato’s variant of CVS.

5. Treatment of CVS

The clinical course of CVS can be divided simply into the episode phase and the well phase, during which the person returns to his or her normal or baseline state of health. 

The episode phase is further divided into the prodrome as the person becomes ill up to the point at which vomiting begins, the vomiting phase, and the recovery phase during which the vomiting ceases and the person returns to baseline health. Each phase has therapeutic implications.

6. CVS plus


Cyclic vomiting syndrome is characterized by severe discrete episodes of nausea, vomiting, and lethargy. Approximately 25% of cases have coexisting neuromuscular disease manifestations (cyclic vomiting syndrome plus).

7. Adult CVS


It has long been thought that CVS was a condition of childhood and adolescence. Now we know that adults also suffer from CVS.

There is CVS that begins in childhood and may extend into adulthood as well as adult onset CVS. As so many adults can attest, the condition causes untold suffering and disability, and often leads to family, school, and career upheaval.

8. Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis Syndrome

Coinciding with the increasing rates of cannabis abuse has been the recognition of a new clinical condition known as Cannabinoid Hyperemesis Syndrome. Cannabinoid Hyperemesis Syndrome is characterized by chronic cannabis use, cyclic episodes of nausea and vomiting, and frequent hot bathing.

Since cyclic vomiting syndrome shares several similarities with CHS, the two conditions are often confused, especially since cannabis (marijuana) use is frequently seen in adults with CVS. 

9. Cyclic vomitingsyndrome and abdominal migraine

Both cyclic vomiting syndrome and abdominal migraine are relatively unusual conditions that present with recurrent and severe paroxysmal vomiting or abdominal pain, separated by periods of weeks or months of good health.

But while cyclic vomiting syndrome is characterized by recurrent, stereotypical episodes of intense nausea and vomiting lasting hours to days, abdominal migraines are characterized by recurrent, acute-onset, incapacitating, non-colicky midline abdominal pain lasting for hours and accompanied by pallor and anorexia.